Essential Role for Synaptopodin in Dendritic Spine Plasticity of the Developing Hippocampus

• DOI: 10.1523/jneurosci.2983-12.2013
• Publication Date: 2013-07-24T22:40:58Z
• Authors: X.-l. Zhang; B. Poschel; C. Faul; C. Upreti; P. K. Stanton; P. Mundel
• Keywords: Synaptopodin

Dendritic spines are a major substrate of brain plasticity. Although many studies have focused on Ca²⁺/calmodulin-dependent protein kinase II (CaMKII)-mediated regulation spine dynamics and synaptic function in adult brain, much less is know about A (PKA)-dependent shape during postnatal development. Synaptopodin dendritic associated modulator actin PKA. Here we show that NMDA cAMP-induced expansion impaired hippocampal slices from 15- 21-d-old synaptopodin-deficient mice. We further synaptopodin required for full expression PKA-dependent long-term potentiation 21-d-old, but not adult, PKA-induced cAMP response element-binding phosphorylation normal the hippocampus mice, suggesting functions independently element-binding. Our results identify as PKA neurons point to an essential role activity-dependent plasticity