A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory

• DOI: 10.1523/jneurosci.3209-06.2006
• Publication Date: 2007-01-10T17:38:33Z
• Authors: Scott H. Soderling; Eric S. Guire; Stefanie Kaech; Jon White; Fang Zhang; Kevin Schutz; Lorene K. Langeberg; Gary Banker; Jacob Raber; John D. Scott
• Keywords: Mice, Knockout; 0303 health sciences; Neuronal Plasticity; Base Sequence; Dendritic Spines; GTPase-Activating Proteins; Molecular Sequence Data; Synaptic Transmission; Rats; Wiskott-Aldrich Syndrome Protein Family; Mice, Inbred C57BL; Rats, Sprague-Dawley; Mice; 03 medical and health sciences; Memory; Animals; Homeostasis; Humans; Amino Acid Sequence; Signal Transduction

The scaffolding protein WAVE-1 (Wiskott-Aldrich syndrome family member 1) directs signals from the GTPase Rac through Arp2/3 complex to facilitate neuronal actin remodeling. WAVE-associated activating called WRP is implicated in human mental retardation, and knock-out mice have altered behavior. Neuronal time-lapse imaging, behavioral analyses, electrophysiological recordings genetically modified were used show that signaling complexes control aspects of morphogenesis synaptic plasticity. Gene targeting experiments demonstrate anchoring a homeostatic mechanism contributes development fidelity connectivity. This implies essential for neural plasticity cognitive