Source-Reconstruction of Event-Related Fields Reveals Hyperfunction and Hypofunction of Cortical Circuits in Antipsychotic-Naive, First-Episode Schizophrenia Patients during Mooney Face Processing

• DOI: 10.1523/jneurosci.3752-13.2014
• Publication Date: 2014-04-23T23:13:07Z
• Authors: Davide Rivolta; Nazareth P. Caste...; Cerisa Stawowsky; Saskia Helbling; Michael Wibral; Christine Grützner; Dagmar Koethe; Katharina Birkner; Laura Kranaster; Frank Enning; Wolf Singer; F. Markus Leweke; Peter J. Uhlhaas
• Keywords: Hyperfunction

Schizophrenia is characterized by dysfunctions in neural circuits that can be investigated with electrophysiological methods, such as EEG and MEG. In the present human study, we examined event-related fields (ERFs), a sample of medication-naive, first-episode schizophrenia (FE-ScZ) patients ( n = 14) healthy control participants 17) during perception Mooney faces to investigate integrity neuromagnetic responses their experience-dependent modification. ERF were analyzed for M100, M170, M250 components at sensor source levels. addition, peak latency adaptation effects due stimulus repetition. FE-ScZ significantly impaired sensory processing, indicated reduced discrimination index (A′). At level, M100 M170 within normal range, whereas response was impaired. However, localization revealed widespread elevated activity delayed latencies responses. not modulated repetitions. The findings suggest may disturbed balance between excitation inhibition could lead failure gate information flow abnormal spreading activity, which compatible dysfunctional glutamatergic neurotransmission.