Investigating the Functional Heterogeneity of the Default Mode Network Using Coordinate-Based Meta-Analytic Modeling

• DOI: 10.1523/jneurosci.4004-09.2009
• Publication Date: 2009-11-19T00:01:28Z
• Authors: Angela R. Laird; Simon B. Eickhoff; Karl Li; Donald A. Robin; David C. Glahn; Peter T. Fox
• Keywords: Human Connectome Project; Task-positive network

The default mode network (DMN) comprises a set of regions that exhibit ongoing, intrinsic activity in the resting state and task-related decreases across range paradigms. However, DMN have also been reported as increases, either independently or coactivated with other network. Cognitive subtractions use low-level baseline conditions generally masked functional nature these regions. Using combination activation likelihood estimation, which assesses statistically significant convergence neuroimaging results, tools distributed BrainMap database, we identified core examined their heterogeneity. Meta-analytic coactivation maps increases were generated for each region, included both within-DMN non-DMN connections. Their properties assessed using behavioral domain metadata BrainMap. These results integrated to determine connectivity model represents patterns interactions observed diverse tasks. Subnetwork components this identified, analysis cliques yielded discrete properties, demonstrating are differentially specialized. Affective perceptual well associated reduced preference motor processing. In summary, used advanced coordinate-based meta-analysis techniques explicate behavior network; future work will involve applying strategy modes brain function, such executive function sensorimotor systems.