HumanROBO1Regulates Interaural Interaction in Auditory Pathways

• DOI: 10.1523/jneurosci.4007-11.2012
• Publication Date: 2012-01-18T19:02:25Z
• Authors: Satu Lamminmäki; Satu Massinen; Jaana Nopola-Hemmi; Juha Kere; Riitta Hari
• Keywords: Magnetoencephalography

In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property mammalian CNS. However, neurodevelopmental function human ROBO1 remains unknown, apart from suggested role in dyslexia. We therefore studied axonal with functional approach, based on magnetoencephalography, 10 dyslexic individuals who all share same rare, weakly expressing haplotype gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that amplitude modulated at different frequencies. found impaired interaural interaction depended dose-dependent manner. Our results indicate normal auditory pathways requires an adequate expression level.