Munc13-Independent Vesicle Priming at Mouse Photoreceptor Ribbon Synapses

• DOI: 10.1523/jneurosci.4240-11.2012
• Publication Date: 2012-06-06T16:43:04Z
• Authors: B. Cooper; M. Hemmerlein; J. Ammermuller; C. Imig; K. Reim; N. Lipstein; S. Kalla; H. Kawabe; N. Brose; J. H. Brandstatter; F. Varoqueaux
• Keywords: Ribbon synapse

Munc13 proteins are essential regulators of exocytosis. In hippocampal glutamatergic neurons, the genetic deletion Munc13s results in complete loss primed synaptic vesicles (SVs) direct contact with presynaptic active zone membrane, and a total block neurotransmitter release. Similarly drastic consequences detectable striatal GABAergic neurons. We show here that, adult mouse retina, two Munc13-2 splice variants bMunc13-2 ubMunc13-2 selectively localized to conventional ribbon synapses, respectively, that is only isoform mature photoreceptor synapses. Strikingly, has little effect on signaling by synapses does not prevent membrane attachment at site. Thus, differ fundamentally regard their dependence SV priming family. Their function moderately affected loss, which leads slight perturbations signal integration retina.