A Selective Role for Neuronal Activity Regulated Pentraxin in the Processing of Sensory-Specific Incentive Value

• DOI: 10.1523/jneurosci.4320-07.2007
• Publication Date: 2007-12-05T19:03:19Z
• Authors: Alexander W. Johnson; Hans S. Crombag; Kogo Takamiya; Jay M. Baraban; Peter C. Holland; Richard L. Huganir; Irving M. Reti
• Keywords: Extinction (optical mineralogy); Anhedonia

Neuronal activity regulated pentraxin (Narp) is a secreted neuronal product which clusters AMPA receptors and regulates excitatory synaptogenesis. Although Narp selectively enriched in brain, its role behavior not known. As expressed prominently limbic regions, we examined whether deletion affects performance on tasks used to assess motivational consequences of food-rewarded learning. knock-out (KO) mice were unimpaired learning simple pavlovian discriminations, instrumental lever pressing, acquisition at least two aspects incentive learning, conditioned reinforcement pavlovian–instrumental transfer. In contrast, resulted substantial deficit the ability use specific outcome expectancies modulate devaluation task. this task, trained respond levers for different rewards. After training, prefed with one rewards, devaluing it. Responding both was then assessed extinction. Whereas control showed significant preference responding associated nondevalued reward, KO responded equally levers, failing suppress devalued reward. Both groups consumed more reward subsequent choice test, indicating could distinguish between rewards themselves. These data suggest has selective processing sensory-specific information necessary appropriate performance, but general effects reward-predictive cues performance.