Acute Hypoxia Activates the Neuroimmune System, Which Diabetes Exacerbates

• DOI: 10.1523/jneurosci.4560-06.2007
• Publication Date: 2007-02-03T01:16:38Z
• Authors: Daniel R. Johnson; Jason C. O'Connor; Matthew E. Hartman; Richard I. Tapping; Gregory G. Freund
• Keywords: Hypoxia; Intermittent hypoxia; Stimulus (psychology)

Acute hypoxia is experienced in an array of ailments and conditions, including asthma, chronic obstructive pulmonary disease, heart failure, sleep apnea, acute hypotension, blast lung injury. Classically, infection activates the neuroimmune system, causing loss interest social environment. We report that non-infectious stimulus triggers system activation (NSA), environment, recovery from hypoxia-induced NSA impaired a mouse model type 2 diabetes. Importantly, behavioral consequences was nearly ablated MyD88 (myeloid differentiation factor 88) knock-out mice intracerebroventricularly administered caspase-1 inhibitor ac-YVAD-CMK (ac-Tyr-Val-Asp-2,6-dimethylbenzoyloxymethylketone). Diabetic had prolonged could be halved by administration subcutaneous interleukin-1 (IL-1) receptor antagonist (RA). These results show IL-1β arm which diabetes exacerbates treatment with IL-1RA ameliorates.