Activation of Spinal Glucagon-Like Peptide-1 Receptors Specifically Suppresses Pain Hypersensitivity

• DOI: 10.1523/jneurosci.4703-13.2014
• Publication Date: 2014-04-09T16:25:24Z
• Authors: Nian Gong; Qi Xiao; Bin Zhu; Chang-Yue Zhang; Yan-Chao Wang; Hui Fan; Ai-Niu Ma; Yong-Xiang Wang
• Keywords: Nerve Injury; Peripheral nerve injury

This study aims to identify the inhibitory role of spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism action rats mice. First, GLP-1Rs were identified be specifically expressed on microglial cells dorsal horn, profoundly upregulated after peripheral nerve injury. In addition, intrathecal GLP-1R agonists GLP-1(7–36) exenatide potently alleviated formalin-, injury-, bone cancer-, diabetes-induced states by 60–90%, without affecting acute nociceptive responses. The antihypersensitive effects GLP-1 completely prevented antagonism gene knockdown. Furthermore, evoked β-endorphin release from both cord cultured microglia. Exenatide antiallodynia was inhibitor minocycline, antiserum, opioid antagonist naloxone. Our results illustrate a novel horn GLP-1R/β-endorphin pathway variety states.