Corticofugal Gating of Auditory Information in the Thalamus: AnIn VivoIntracellular Recording Study

• DOI: 10.1523/jneurosci.4897-03.2004
• Publication Date: 2004-03-24T20:33:54Z
• Authors: Yan-Qin Yu; Ying Xiong; Ying-Shing Chan; Jufang He
• Keywords: Medial geniculate body; Hyperpolarization

In the present study, we investigated auditory responses of medial geniculate (MGB) neurons, through in vivo intracellular recordings anesthetized guinea pigs, while cortex was electrically activated. Of 63 neurons that received corticofugal modulation membrane potential, 30 potentiation and 33 hyperpolarization. The potential (amplitude, mean ± SD, 8.6 5.5 mV; duration, 125.5 75.4 msec) facilitated spontaneous firing MGB neurons. hyperpolarization –11.3 4.9 mV amplitude 210.0 210.1 msec duration suppressed Four five were histologically confirmed to be located lemniscal facilitatory modulation, all four non-lemniscal inhibitory modulation. recording provides novel results on how projection gates sensory information thalamus: via spatially selective depolarization It is speculated systematic selectivity facilitation inhibition over related attention shift within modality across modalities.