Inhibition of CNS Remyelination by the Presence of Semaphorin 3A

• DOI: 10.1523/jneurosci.4930-10.2011
• Publication Date: 2011-03-09T18:40:31Z
• Authors: Yasir A. Syed; Elisabeth Hand; Wiebke Möbius; Chao Zhao; Matthias Hofer; Klaus A. Nave; Mark R. Kotter
• Keywords: Remyelination; SEMA3A; Plexin

Failure of oligodendrocyte precursor cell (OPC) differentiation has been recognized as the leading cause for failure myelin regeneration in diseases such multiple sclerosis (MS). One explanation OPC MS is presence inhibitory molecules demyelinated lesions. So far only a few substrates have identified Semaphorin 3A (Sema3A), secreted member semaphorin family, can act repulsive guidance cue neuronal and glial cells CNS. Recent studies suggest that Sema3A also expressed active However, implication expression lesions remains unclear OPCs are commonly present chronic In study we identify potent, selective, reversible inhibitor vitro . Furthermore, show administration into demyelinating rat CNS results remyelination. Our imply an important role block occurring