Activity of Pontine Neurons during Sleep and Cataplexy in Hypocretin Knock-Out Mice

• DOI: 10.1523/jneurosci.5151-08.2009
• Publication Date: 2009-02-04T18:33:35Z
• Authors: Stephen Thankachan; Satvinder Kaur; Priyattam J. Shir...
• Keywords: Pons; Muscle tone; Sleep; Sleep paralysis

Narcolepsy is a human sleep disorder resulting from the loss of neurons containing neuropeptide orexin, also known as hypocretin. Cataplexy, which sudden muscle tone during waking, an important diagnostic symptom narcolepsy. In humans and canines with narcolepsy, cataplexy considered to be separate distinct behavioral state. However, in mouse model disease this issue not resolved. The present study monitored activity forty four rostral pons hypocretin knock-out mice. Majority were active wake REM sleep, while selectively sleep. All these less compared Thus, although share many common features, including atonia, state