Coupling between Beta and High-Frequency Activity in the Human Subthalamic Nucleus May Be a Pathophysiological Mechanism in Parkinson's Disease

• DOI: 10.1523/jneurosci.5459-09.2010
• Publication Date: 2010-05-12T17:43:42Z
• Authors: Jon López-Azcárate; Mikel Tainta; María C. Rodrígue...; Miguel Valencia; Rafael González; Jorge Guridi; Jorge Iriarte; José A. Obeso; Julio Artieda; Manuel Alegre
• Keywords: Subthalamic Nucleus; Local field potential; BETA (programming language); Beta Rhythm; Pathophysiology; Premovement neuronal activity

In Parkinson's disease (PD), the oscillatory activity recorded from basal ganglia shows dopamine-dependent changes. “off” parkinsonian motor state, there is prominent in beta band (12–30 Hz) that mostly attenuated after dopaminergic therapy (“on” medication state). The on state also characterized by gamma (60–80 and high-frequency (300 bands modulated movement. We local field potentials a group of 15 PD patients (three females) treated with bilateral deep brain stimulation subthalamic nucleus, using high sampling rate (2 kHz) filters suitable to study (0.3–1000 Hz). observed oscillations (HFOs) both off states. amplitude HFOs was coupled phase abnormal activity. beta-coupled showed little or even negative movement-related changes amplitude. Moreover, degree modulation correlated negatively rigidity/bradykinesia scores. were liberated this coupling, they displayed marked modulation. Cross-frequency interactions between slow activities fast frequencies have been attributed an important role information processing cortical structures. Our findings suggest nonlinear coupling may not only be physiological mechanism (as shown previously) but it participate pathophysiology parkinsonism.