sTREM 2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early‐stage Alzheimer's disease and associate with neuronal injury markers

• DOI: 10.15252/emmm.201506123
• Publication Date: 2016-03-04T02:13:35Z
• Authors: Marc Suárez‐Calvet; Gernot Kleinberger; Miguel Ángel Araq...; Matthias Brendel; Axel Rominger; Daniel Alcolea; Juan Fortea; Alberto Lleó; Rafael Blesa; Juan Domingo Gispert; Raquel Sánchez‐Valle; Anna Antonell; Lorena Rami; José L Molinuevo; Frederic Brosseron; Andreas Traschütz; Michael T Heneka; Hanne Struyfs; Sebastiaan Engelb...; Kristel Sleegers; Christine Van Bro...; Henrik Zetterberg; Bengt Nellgård; Kaj Blennow; Alexander Crispin; Michael Ewers; Christian Haass
• Keywords: Male; Medicine (General); microglia; metabolism [Microglia]; QH426-470; Alzheimer's Disease; pathology [Alzheimer Disease]; 03 medical and health sciences; R5-920; 0302 clinical medicine; Alzheimer Disease; chemistry [Cerebrospinal Fluid]; Genetics; TREM2; Humans; ddc:610; Neurodegeneration; Receptors, Immunologic; Biology; Research Articles; Aged; Cerebrospinal Fluid; Aged, 80 and over; Membrane Glycoproteins; TREM2 protein, human; diagnosis [Alzheimer Disease]; neurodegeneration; biomarkers; Alzheimer's disease; Middle Aged; 3. Good health; Cross-Sectional Studies; cerebrospinal fluid [Biomarkers]; Female; Human medicine; Microglia; cerebrospinal fluid [Membrane Glycoproteins]; Biomarkers

TREM2 is an innate immune receptor expressed on the surface of microglia. Loss-of-function mutations are associated with increased risk Alzheimer's disease (AD). a type-1 protein ectodomain that proteolytically cleaved and released into extracellular space as soluble variant (sTREM2), which can be measured in cerebrospinal fluid (CSF). In this cross-sectional multicenter study, we investigated whether CSF levels sTREM2 changed during clinical course AD, cognitively normal individuals suspected non-AD pathology (SNAP). were higher mild cognitive impairment due to AD than all other groups controls. SNAP also had significantly compared Moreover, total tau phospho-tau181P, markers neuronal degeneration pathology. Our data demonstrate early symptomatic phase probably reflecting corresponding change microglia activation status response degeneration.