COCO/DAND5 inhibits developmental and pathological ocular angiogenesis

• DOI: 10.15252/emmm.202012005
• Publication Date: 2021-02-18T07:10:27Z
• Authors: Natalija Popovic; Erika Hooker; Andrea Barabino; Anthony Flamier; Frédéric Provost; Manuel Buscarlet; Gilbert Bernier; Bruno Larrivée
• Keywords: Coco

Neovascularization contributes to multiple visual disorders including age-related macular degeneration (AMD) and retinopathy of prematurity. Current therapies for treating ocular angiogenesis are centered on the inhibition vascular endothelial growth factor (VEGF). While clinically effective, some AMD patients refractory or develop resistance anti-VEGF concerns increased risks developing geographic atrophy following long-term treatment have been raised. Identification alternative pathways inhibit pathological is thus important. We identified a novel inhibitor angiogenesis, COCO, member Cerberus-related DAN protein family. demonstrate that COCO inhibits sprouting, migration cellular proliferation cultured cells. Intravitreal injections inhibited retinal vascularization during development in models equally abrogated choroidal neovascularization. Mechanistically, TGFβ BMP altered energy metabolism redox balance Together, these data show an possibly representing therapeutic option neovascular diseases.