Three years of growth hormone treatment in growth hormone-deficient adults: near normalization of body composition and physical performance

• DOI: 10.1530/eje.0.1300224
• Publication Date: 2008-12-15T21:19:42Z
• Authors: Jens OL Jørgensen; Leif Thuesen; Jørn Müller; Per Ovesen; Niels E Skakkebæk; Jens S Christiansen
• Keywords: Normalization; Growth hormone treatment

Jørgensen JOL, Thuesen L, Müller J, Ovesen P, Skakkebæk NE, Christiansen JS. Three years of growth hormone treatment in hormone-deficient adults: near normalization body composition and physical performance. Eur J Endocrinol 1994;130:224–8. ISSN 0804–4643 Growth (GH) replacement therapy several controlled short-term trials have shown unanimous beneficial effects on other features. To evaluate more long-term we report data from 3 uninterrupted GH 10 GH-deficient adults who had all completed a previous double-blind placebo-controlled study also been studied after 16 months open therapy. No further increase linear height was observed. The initial thigh muscle volume maintained A slight weight fat recorded. Exercise capacity isometric strength were increased significantly compared to the placebo period. This associated with stabilized levels resting heart rate blood pressure. Glycosylated hemoglobin normal did not change during study. standard oral glucose tolerance test performed at end revealed no evidence intolerance. side-effects reported. Compared an age- sex-matched group healthy untreated subjects, volume, exercise become normalized subnormal We conclude that is preserved performance, resulting previously abnormal features adding new merits this modality. Jens OL Jørgensen, Medical Department M (Endocrinology Diabetes), Aarhus Kommunehospital, DK-8000C, Denmark