Identification of Mom7, a Novel Modifier of ApcMin/+ on Mouse Chromosome 18

• DOI: 10.1534/genetics.107.071217
• Publication Date: 2007-04-16T00:32:51Z
• Authors: Lawrence N Kwong; Alexandra Shedlovsky; Bryan S Biehl; Linda Clipson; Cheri A Pasch; William F Dove
• Keywords: Identification

The Apc(Min) mouse model of colorectal cancer provides a discrete, quantitative measurement tumor multiplicity, allowing for robust trait locus analysis. This advantage has previously been used to uncover polymorphic modifiers the Min phenotype: Mom1, which is partly explained by Pla2g2a; Mom2, spontaneous mutant modifier; and Mom3, was discovered in an outbred cross. Here, we describe localization novel modifier, Mom7, pericentromeric region chromosome 18. Mom7 mapped crosses involving four inbred strains: C57BL/6J (B6), BTBR/Pas (BTBR), AKR/J (AKR), A/J. There are at least two distinct alleles Mom7: recessive, enhancing BTBR, AKR, A/J dominant, suppressive B6 allele. Homozygosity increases number approximately threefold small intestine on both F(1) backgrounds. Congenic line analysis narrowed within 7.4 Mb centromere, 28 proximal Apc. Analysis SNP data from various genotyping projects suggests that could be as 4.4 there may five or more segregating among many strains mice. implications experiments comparisons between different mixed genetic