Long-Term Memory inDrosophilaIs Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9

• DOI: 10.1534/genetics.115.183194
• Publication Date: 2016-05-07T13:52:46Z
• Authors: Silvia Schwartz; Mauro Truglio; Maxwell J Scott; Helen L Fitzsimons
• Keywords: HDAC4; Histone deacetylase 5

HDAC4 is a potent memory repressor with overexpression of wild type or nuclear-restricted mutant resulting in deficits. Interestingly, reduction also impairs via an as yet unknown mechanism. Although histone deacetylase family members are important mediators epigenetic mechanisms neurons, predominantly cytoplasmic the brain and there increasing evidence for interactions nonhistone proteins, suggesting has roles beyond transcriptional regulation. To that end, we performed genetic interaction screen Drosophila identified 26 genes interacted HDAC4, including Ubc9, sole SUMO E2-conjugating enzyme. RNA interference-induced Ubc9 adult impaired long-term courtship suppression assay, model associative memory. We demonstrate interact genetically during formation, opening new avenues investigating through which regulates formation other neurological processes.