Fluctuating Selection in the Moran

• DOI: 10.1534/genetics.116.192914
• Publication Date: 2017-01-21T02:50:44Z
• Authors: Antony M Dean; Clarence Lehman; Xiao Yi
• Keywords: Directional selection; Effective population size; Neutral mutation; Population Genetics; Balancing selection; Frequency-dependent selection; Stabilizing selection

Contrary to classical population genetics theory, experiments demonstrate that fluctuating selection can protect a haploid polymorphism in the absence of frequency dependent effects on fitness. Using forward simulations with Moran model, we confirm our analytical results showing regime, mean coefficient zero, promotes polymorphism. We find increases heterozygosity over neutral expectations are especially pronounced when fluctuations rapid, mutation is weak, size large, and variance big. Lowering makes more directional, so declines. also show raises