The Effect of Lactobacillus reuteri Supplementation in Adults with Chronic Functional Constipation: a Randomized, Double-Blind, Placebo-Controlled Trial*

• DOI: 10.15403/jgld.2014.1121.234.elr
• Publication Date: 2014-12-03T12:59:35Z
• Authors: Veronica Ojetti; Gianluca Ianiro; Annalisa Tortora; Giovanna D‘Angelo; Teresa Antonella ...; Stefano Bibbò; Alessio Migneco; Antonio Gasbarrini
• Keywords: Lactobacillus reuteri; Functional constipation

Background & Aims: There is a growing interest for the use of probiotics chronic constipation. A recent randomized controlled trial (RCT) showed positive effect Lactobacillus reuteri (L. reuteri) on bowel movement frequency in infants with The aim present study was to evaluate effects L. adult patients functional constipation.Methods: double-blind, placebo RCT conducted 40 adults (18M/22F, 35±15 years) affected by constipation according Rome III criteria. Patients were randomly assigned receive supplementation (DSM 17938), or matching 4 weeks. increase movements/week primary outcome, while improvement stool consistency secondary outcome.Results: At week 4, mean 2.6 (SD±1.14, 95% CI:1.6-3.6) group and 1.0 (SD±1. CI:0.12-1.88) (p=0.046). end treatment, 5.28±1.93 3.89±1.79 group. not significant difference between two groups.Conclusions: more effective than improving as previously demonstrated children, even if it seems have no consistency.