Predictors of left ventricular thrombus formation and delayed resolution in post-acute myocardial infarction and severe left ventricular dysfunction

• DOI: 10.15406/jccr.2024.17.00613
• Publication Date: 2025-03-14T10:09:50Z
• Authors: Ali Ahmed Youssef; Shaima Mohammed A...; Mustafa Ali Alrefae; Hesham Hussein Kh...; Reem Abdulraouf H...; Ahmad Yousef Soliman; Omar Mohamed Saleh
• Keywords: Left Ventricular Thrombus; Left Ventricles

Background: The predictors of left ventricular thrombus (LVT) formation and resolution, post-acute myocardial infarction (MI), (LV) dysfunction significantly impact management strategies need updating to reflect contemporary practice. Methods: Transthoracic echocardiography was used screen assess MI patients with LV ejection fraction (LVEF) <35% or <40% apical akinesis dyskinesis. Results: We enrolled 979 patients. Of them, 67 (6.84%) had an LVT at the baseline. Additionally, 22 7 developed new 1 3 months. were presence aneurysm (HR: 1.45, 95% CI: 1.11-2.07, P=0.024), wall motion score index (WMSI) 1.36, 1.07-2.82, P=0.036), late presentation after 1.32, 1.16-3.16, P=0.042), older age 1.24, 1.08-3.36, P=0.043), lower baseline LVEF 1.23, 1.06-2.75, P=0.046) higher level low-density lipoprotein-cholesterol (LDL-C) 1.18, 1.02-2.54, P=0.049). resolved in 40 (59.7%) 32 (65.3%) months, respectively. persistence beyond months 1.55, 1.03-1.87, size 1.43, 1.32-2.74, P=0.031), WMSI 1.29, P=0.043) 1.07-2.16, P=0.047). Conclusions: global systolic dysfunction, age, presentation, high LDL-C predict post-MI. These factors findings should guide anticoagulation therapy this high-risk population.