Glucose and Lipid Metabolism in Small For Gestational Age Infants at 48 Hours of Age

• DOI: 10.1542/peds.111.4.804
• Publication Date: 2004-08-14T00:43:47Z
• Authors: Rodrigo A. Bazaes; Teresa E. Salazar; Enrica Pittaluga; Verónica Peña; Angélica Alegría; Germán Íñiguez; Ken K. Ong; David B. Dunger; M. Verónica Mericq
• Keywords: Carbohydrate Metabolism

Objective. To study the consequences of low birth weight on glucose and lipid metabolism 48 hours after delivery. Methods. We studied 136 small for gestational age (SGA) 34 appropriate (AGA) term neonates who were born in Santiago, Chile. Prefeeding venous blood was obtained determination glucose, free fatty acids, β-hydroxy butyrate, insulin, C-peptide, leptin, sex hormone-binding globulin, insulin-like growth factor-binding protein-1 (IGFBP-1), cortisol. Results. SGA newborns had lower (SGA versus AGA, median [interquartile range]: 3.6 mmol/L [2.9–4.1 mmol/L] vs 3.9 [3.6–4.6 mmol/L]) insulin levels (31.3 pmol/L [20.8–47.9 pmol/L] 62.5 [53.5–154.9]) than AGA infants, they higher glucose/insulin ratios (13.9 mg/dL/uIU/mL [8.6–19.1 mg/dL/uIU/mL] 8.2 [4.6–14.1 mg/dL/uIU/mL]). infants also IGFBP-1 (5.1 nmol/L [4.4–6.7 nmol/L] 2.9 nmol/l [1.4–4.2 nmol/L]), acids (0.72 mEq/L [0.43–1.00 mEq/L] 0.33 [0.26–0.54 mEq/L]) butyrate (0.41 [0.15–0.91 0.09 [0.05–0.13 mEq/L]). Sex-hormone binding globulin not significantly different between 2 groups. Conclusions. In early postnatal life, display an increased sensitivity with respect to disposal but suppression lipolysis, ketogenesis, hepatic production IGFBP-1. It will be important determine how these differential sensitivities vary increasing age.