Sleep Apnea in Children With Down Syndrome

• DOI: 10.1542/peds.2022-058771
• Publication Date: 2023-02-10T08:07:58Z
• Authors: Katelyn Seither; Benjamin M. Helm; Christine Heubi; Daniel Swarr; Kristen R. Suhrie
• Keywords: Laryngomalacia; Failure to Thrive; Sleep study; Medical record

OBJECTIVE The authors of this study aimed to evaluate the use polysomnography (PSG) in children with Down syndrome (DS) between ages 0 and 7 years, assess prevalence severity obstructive sleep apnea (OSA) associated comorbidities, describe interventions used for OSA. METHODS A retrospective cohort was performed at Cincinnati Children’s Hospital Medical Center DS born 2013 2019. Data were extracted from electronic medical record, including demographics, age PSG, PSG results, after an abnormal PSG. Statistical analysis included unadjusted bivariate association testing multivariable logistic regression modeling investigate associations OSA severity. RESULTS Among 397 patients cohort, 59% (n = 235) had a documented 94% 221) 60% 141) demonstrating moderate or severe There inverse relationship (P < .001). In multiple model, increased rates failure thrive .01), aspiration .02), laryngomalacia .01). After surgical intervention, 73% experienced resolution improvement CONCLUSION pediatric DS, identified most frequently first year life. addition, prompt evaluation symptomatic infants, our data support earlier screening requiring neonatal ICU care those feeding difficulties, airway abnormalities, and/or pulmonary hypertension given their risk