A Bundled, Practice-Based Intervention to Increase HPV Vaccination

• DOI: 10.1542/peds.2024-068145
• Publication Date: 2025-01-06T00:03:45Z
• Authors: Peter G. Szilagyi; Alexander G. Fiks; Cynthia M. Rand; Mary Kate Kelly; A. Russell Localio; Christina S. Albe...; Sharon G. Humiston; Robert W. Grundmeier; Jennifer Steffes; Kristin Davis; Laura P. Shone; Greta McFarland; Dianna E. Abney; Alisa J. Stephens...

Human papillomavirus (HPV) vaccination rates are suboptimal, and missed opportunities common. We hypothesized that a bundled intervention improves HPV opportunities. used pre-post design to assess differences in vaccine (visits when vaccine-eligible adolescents not vaccinated). compared for 12-month period before vs those 6-month (February 23, 2022, August 9, 2022) during intervention. implemented the 24 primary care pediatric practices had been usual controls prior randomized trial. The involved 3 components: online clinician training on communication, performance feedback opportunities, prompts vaccination. As secondary analysis, we these 48 contemporaneous comparison group identified retrospectively. For well-child (WCC) visits, were improved by 4.8 percentage points (95% CI, -7.2% -2.4%) initial doses modest 2.2 -4.4% -0.0%) subsequent doses. other visit types, findings ruled out changes beyond minimal improvements. Missed opportunity at WCC visits similar 4.5-year intervention, but they worsened (difference, -6.6%; 95% -9.3% -3.8%). This appeared improve visits.