Neuroradiographic Findings in the Newborn Period and Long-term Outcome in Children With Symptomatic Congenital Cytomegalovirus Infection

• DOI: 10.1542/peds.99.3.409
• Publication Date: 2004-08-13T23:40:17Z
• Authors: Suresh B. Boppana; Karen B. Fowler; Yoginder Vaid; Gary Hedlund; Sergio Stagno; William J. Britt; Robert F. Pass
• Keywords: Sequela; Cytomegalovirus

Objective. To determine whether newborn cranial computed tomographic (CT) scan abnormalities predict an adverse neurodevelopmental outcome in children with symptomatic congenital cytomegalovirus (CMV) infection and to examine the association between clinical findings at birth imaging abnormalities. Methods. The data from 56 CMV who underwent CT scans as newborns were enrolled a long-term follow-up study analyzed. incidence of sequelae was compared groups normal abnormal studies. relationship results other also examined. Results. Abnormal noted 70% subjects; intracerebral calcification most frequent finding. Most (90%) developed least one sequela, 29% those study. Only 1 child had IQ <70, contrast 59% In addition, almost half <50 none scan. Newborn associated hearing screen loss on follow-up. None neonatal neurologic predictive Conclusion. neonates infection, is good predictor outcome. laboratory did not neuroradiographic infection.