Infants with Congenital Disorders Identified Through Newborn Screening — United States, 2015–2017

• DOI: 10.15585/mmwr.mm6936a6
• Publication Date: 2020-09-10T16:01:27Z
• Authors: Marci K. Sontag; Careema Yusuf; Scott D. Grosse; Sari Edelman; Joshua I. Miller; Sarah McKasson; Yvonne Kellar-Gue...; Marcus Gaffney; Cynthia F. Hinton; Carla Cuthbert; Sikha Singh; Jelili Ojodu; Stuart K. Shapira
• Keywords: Congenital hypothyroidism

Newborn screening (NBS) identifies infants at risk for congenital disorders which early intervention has been shown to improve outcomes (1). State public health programs are encouraged screen on the national Recommended Uniform Screening Panel (RUSP), increased from 29 in 2005 35 2018.* The RUSP includes hearing loss (HL) and critical heart defects, can be detected through point-of-care screening, 33 laboratory of dried blood spot (DBS) specimens. Numbers cases (32 DBS HL) reported by 50 U.S. state were tabulated. three subtypes sickle cell disease (SCD) listed as separate (S,S disease; S,beta-thalassemia; S,C disease) combined current analysis, frequencies resulting calculated relative annual births. During 2015-2017, overall prevalence was 34.0 per 10,000 live Applying that frequency 3,791,712 births 2018,† approximately 12,900 expected identified each year with one included study. most prevalent disorder is HL (16.5 10,000), primary hypothyroidism (CH) (6.0 SCD (4.9 cystic fibrosis (CF) (1.8 10,000). Notable changes these have occurred since previous estimates based 2006 (2). number a level highlights effect NBS having infant detection, intervention, potential improved health, regardless geographic, racial/ethnic, or socioeconomic differences.