Disease Severity of Respiratory Syncytial Virus Compared with COVID-19 and Influenza Among Hospitalized Adults Aged ≥60 Years — IVY Network, 20 U.S. States, February 2022–May 2023

• DOI: 10.15585/mmwr.mm7240a2
• Publication Date: 2023-10-05T16:04:42Z
• Authors: Diya Surie; Katharine A. Yuen...; Jennifer DeCuir; Yuwei Zhu; Manjusha Gaglani; Adit A. Ginde; H. Keipp Talbot; Jonathan D. Casey; Nicholas M. Mohr; Shekhar Ghamande; Kevin W. Gibbs; D. Clark Files; David N. Hager; Harith Ali; Matthew E. Prekker; Michelle N. Gong; Amira Mohamed; Nicholas J. Johnson; Jay S. Steingrub; Ithan D. Peltan; Samuel M. Brown; Aleda M. Leis; Akram Khan; Catherine L. Hough; William S. Bender; Abhijit Duggal; Jennifer G. Wilson; Nida Qadir; Steven Y. Chang; Christopher Mallow; Jennie H. Kwon; Matthew C. Exline; Adam S. Lauring; Nathan I. Shapiro; Cristie Columbus; Ivana A. Vaughn; Mayur Ramesh; Basmah Safdar; Natasha Halasa; James D. Chappell; Carlos G. Grijalva; Adrienne Baughman; Todd W. Rice; Kelsey N. Womack; Jin H. Han; Sydney A. Swan; Indrani Mukherjee; Nathaniel M. Lewis; Sascha Ellington; Meredith L. McMorrow; Emily T. Martin; Wesley H. Self
• Keywords: Nasal cannula

On June 21, 2023, CDC's Advisory Committee on Immunization Practices recommended respiratory syncytial virus (RSV) vaccination for adults aged ≥60 years, offered to individual using shared clinical decision-making.Informed use of these vaccines requires an understanding RSV disease severity.To characterize RSV-associated severity, 5,784 years hospitalized with acute illness and laboratory-confirmed RSV, SARS-CoV-2, or influenza infection were prospectively enrolled from 25 hospitals in 20 U.S. states during February 1, 2022-May 31, 2023.Multivariable logistic regression was used compare severity COVID-19 the basis following outcomes: 1) standard flow (<30 L/minute) oxygen therapy, 2) high-flow nasal cannula (HFNC) noninvasive ventilation (NIV), 3) intensive care unit (ICU) admission, 4) invasive mechanical (IMV) death.Overall, 304 (5.3%) 4,734 (81.8%) 746 (12.9%) influenza.Patients more likely receive oxygen, HFNC NIV, ICU admission than those IMV die compared patients (adjusted odds ratio = 2.08; 95% CI 1.33-3.26).Among older adults, less common, but associated severe influenza.High is important consider decision-making regarding vaccination.