Principles of Diagnosis and Personalized Treatment of Hereditary Colorectal Cancer

• DOI: 10.15690/vramn1083
• Publication Date: 2019-05-31T01:42:55Z
• Authors: Alexey S. Tsukanov; Yury A. Shelygin; Sergey I. Achkasov; Sergey A. Frolov; Vladimir N. Kashn...; Alexander M. Kuzm...; Dmitry Yu. Pikunov; Vitaly P. Shubin
• Keywords: Lynch Syndrome; Personalized Medicine; Genetic diagnosis; Identification

The most frequent forms of hereditary colorectal cancer syndromes are Lynch syndrome and familial adenomatous polyposis (FAP). All the patients with suspicion to these need precise clinical genetic diagnostics. Affected personalized program treatment because standard algorithm cannot be considered sufficiently effective. Identification a pathogenic mutation in patient indicates for DNA diagnostics his close relatives only this case all carriers germline mutations can included high-risk group. Algorithms monitoring operative were developed different countries. However, populations have their own features. aim work was highlight principles diagnosis cancer, taking into account international Russian recommendations.