Partial Volume Correction on ASL-MRI and Its Application on Alzheimer's Disease Diagnosis

• DOI: 10.1587/transinf.2014edp7104
• Publication Date: 2014-11-01T00:00:54Z
• Authors: Wenji YANG; Wei HUANG; Shanxue CHEN
• Keywords: Partial volume; Arterial spin labeling; Voxel-based morphometry

Arterial spin labeling (ASL) is a non-invasive magnetic resonance imaging (MRI) method that can provide direct and quantitative measurements of cerebral blood flow (CBF) scanned patients. ASL be utilized as an modality to detect Alzheimer's disease (AD), brain atrophy AD patients revealed by low CBF values in certain regions. However, partial volume effects (PVE), which mainly caused signal cross-contamination due voxel heterogeneity limited spatial resolution images, often prevents from being precisely measured. In this study, novel PVE correction proposed based on pixel-wise voxels images; it well handle with the existing problems blurring loss details conventional methods. Dozens comparison experiments statistical analysis also suggest superior other methods diagnosis real data.