Consensus on the treatment of autoimmune bullous dermatoses: pemphigus vulgaris and pemphigus foliaceus - Brazilian Society of Dermatology

• DOI: 10.1590/abd1806-4841.2019940206
• Publication Date: 2019-06-01T19:51:24Z
• Authors: Adriana Maria Porro; Günter Hans Filho; Claudia Giuli Santi
• Keywords: Pemphigus vulgaris; Pemphigus foliaceus; Dapsone; Prednisolone

Pemphigus are intraepidermal autoimmune bullous dermatoses that occur with lesions on the skin and / or mucous membranes. The most frequent types pemphigus vulgaris foliaceus (classic endemic). This consensus aims to present a complete updated review of treatment these two more forms pemphigus, based literature personal experience authors. In moderate severe cases foliaceus, systemic corticosteroid therapy (prednisone prednisolone) is choice. Adjuvant drugs, usually immunosuppressive drugs (azathioprine, mycophenolate mofetil, methotrexate, cyclophosphamide) may be prescribed as sparers in refractory contraindications corticosteroids minimize side effects. nonresponsive cases, form intravenous pulse therapy, immunoglobulin plasmapheresis immunoadsorption can administered. Immunobiological particularly rituximab, appear promising alternative. For milder smaller doses oral corticosteroid, dapsone topical options. At end flowcharts presented suggestions for therapeutic approach patients foliaceus.