The effect of Allium sativum in experimental peritoneal adhesion model in rats

• DOI: 10.1590/s0102-865020190100000002
• Publication Date: 2019-12-09T20:26:55Z
• Authors: Uğur Topal; Nuri Emrah Göret; Ceren Canbey Göret; Ömer Faruk Özkan
• Keywords: Cecum; Abrasion (mechanical)

To evaluate the effect of garlic on formation postoperative adhesions in rats.Twenty-four Sprague dawley rats were divided into three groups. In Group 1 (sham), laparotomy was performed and stitched up. 2 (control), after performed, punctate hemorrhage induced by cecal abrasion cecum cc saline intraperitoneally administered to each rat. 3 (experimental), rat a sterile Allium sativum derivative. The all groups re-laparotomized day 7; samples obtained from peritoneal tissue surrounding cecum.In 3, there statistically significant difference terms inflammation, lymph node size, free oxygen radicals; these parameters tended increase. fibrosis evaluated using H&E MT, no between 3.No positive outcomes indicating that reduces intra-abdominal obtained. However, it caused severe inflammation tissue. Additionally, immunohistochemical analyses conducted detect oxidative stress, allium increased production radicals