Jaggery Protects Hepatorenal Injury Induced by Acute Exposure to Carbon Tetrachloride in Wistar rats

• DOI: 10.1615/jenvironpatholtoxicoloncol.2013006793
• Publication Date: 2013-02-07T20:35:28Z
• Authors: Chandra Kant Sharma; Monika Saxena; Vinay Sharma
• Keywords: Jaggery; Toxicant

In this study, we evaluated the protective activity of aqueous extract jaggery against CCl4-induced hepatic−renal damage in rats. Jaggery was administered one group at doses 250, 500 and 750 mg/ kg body weight (bwt) (p.o., once only), CCL4 another a dose 1.5 ml/kg bwt (i.p., only) to evaluate effect on induced oxidative Various blood tissue biochemical studies were performed. The administration toxicant significantly altered variables. Hepatic renal lipid peroxidation (LPO) levels increased significantly, whereas considerable depletion observed reduced glutathione (GSH) level after intoxication. A remarkable decrease activities adenosine triphosphatase (ATPase) glucose-6-phosphatase (G-6-Pase) induction toxicity. Treatment with three different all measured variables, but greater hepatic-renal protection higher (750 mg/kg bwt) than lower does (250 bwt). also reversed histopathological alterations. Thus, it may be concluded that can used reduce hepatic serve as an alternative medicine etiology.