Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice

• DOI: 10.1615/jenvironpatholtoxicoloncol.v26.i4.10
• Publication Date: 2012-07-26T14:51:44Z
• Authors: Arindam Bhattacha...; Debaprasad Mandal; Lakshmishri Lahiry; Sankar Bhattacharyya; Sreya Chattopadhyay; Uttam K. Ghosh; Gaurisankar Sa; Tanya Das
• Keywords: Ehrlich ascites carcinoma

It is recognized that during cancer, the disease itself as well many of anticancer drugs in use produce undesirable side effects such hepatotoxicity. We have already demonstrated antitumor and immunorestoring black tea. Here we report Ehrlich's ascites carcinoma (EAC)—induced hepatotoxicity its protection by dose tea mice. Hepatotoxicity was adjudged liver histopathology measurement plasma level alkaline phosphatase (ALP). An attempt to delineate underlying mechanisms revealed tumor-induced generation reactive oxygen species (ROS) on one hand depression antioxidants neutralize ROS, i.e., superoxide dismutase (SOD), catalase, reduced glutathione (GSH), glutathione-S-transferase (GST), other. As a result, lipid peroxidation, which leads damage host cell components, increased. Treatment with could replenish host's antioxidant system regress cancer-induced ROS significantly, thereby protecting from peroxidation subsequent degeneration. Thus, unlike other agents, not only has properties, but it also protects toxicity. These results thus raise possibility inclusion successful therapeutic regimen against cancer.