Polo-Like Kinase 4 Correlates with Aggressive Tumor Characteristics, Shortened Disease-Free Survival and Overall Survival in Patients with Cutaneous Melanoma who Undergo Surgical Resection

• DOI: 10.1620/tjem.2023.j092
• Publication Date: 2023-11-08T22:14:01Z
• Authors: Ling Zhang; Shenglan Zhang; Zhao Han; Zhao Liu; Yanyan Xu; Xiaojing Li; Guoying Miao; Liang Niu
• Keywords: Interquartile range

Polo-like kinase 4 (PLK4) involves in tumor progression via regulating centriole duplication. This study aimed to investigate correlations of PLK4 with characteristics and survival cutaneous melanoma patients undergoing surgical resection. Tumor specimens 43 were retrieved for determination by immunohistochemistry (IHC). The IHC score was a multiplication staining intensity percentage staining-positive cells. found the median mean 0.0 (interquartile range: 0.0-6.0) 3.5 ± 3.2 (mean SD), respectively. Elevated correlated lymph node metastasis (P = 0.028), higher (TNM) stage 0.004), adjuvant therapy =0.029). > 0 did not relate disease-free (DFS) or overall (OS) (both P 0.050). 3 associated decreased DFS 0.027), but OS 0.098). Five-year rate 75.0% 53.9%, correspondingly; while ≤ 81.0% 37.5%, 100.0% 66.3%, accordingly; whereas 85.7% 61.5%, correspondingly. According forward-step multivariate analysis, neither nor independently related worse (all Further validation THE HUMAN PROTEIN ATLAS database showed high RNA expression shortened 0.001). correlates metastasis, increased TNM stage, poor