Cytogenetic Effects of High-Energy Iron Ions: Dependence on Shielding Thickness and Material

• DOI: 10.1667/rr3362.1
• Publication Date: 2006-07-17T21:10:29Z
• Authors: M. Durante; K. George; G. Gialanella; G. Grossi; C. La Tessa; L. Manti; J. Miller; M. Pugliese; P. Scampoli; F. A. Cucinotta
• Keywords: Relative biological effectiveness

Durante, M., George, K., Gialanella, G., Grossi, La Tessa, C., Manti, L., Miller, J., Pugliese, Scampoli, P. and Cucinotta, F. A. Cytogenetic Effects of High-Energy Iron Ions: Dependence on Shielding Thickness Material. Radiat. Res. 164, 571–576 (2005).We report results for chromosomal aberrations in human peripheral blood lymphocytes after they were exposed to high-energy iron ions with or without shielding at the HIMAC, AGS NSRL accelerators. Isolated energies between 200 5000 MeV/ nucleon 0.1–1-Gy dose range. materials consisted polyethylene, lucite (PMMA), carbon, aluminum lead, mass thickness ranging from 2 30 g/cm2. After exposure, stimulated grow vitro, chromosomes prematurely condensed using a phosphatase inhibitor (calyculin A). Aberrations scored FISH painting. The yield total interchromosomal exchanges (including dicentrics, translocations complex rearrangements) increased linearly fluence range studied. decreased effectiveness per unit ions. highest RBE value was measured 1 GeV/nucleon iron-ion beam NSRL. However, induction apparently is not well correlated mean LET. When increased, frequency particle incident shield 500 MeV/nucleon Maximum variation equal obtained light (polyethylene, carbon PMMA). Variations follow variations behind but can be modified by different mixed radiation field produced nuclear fragmentation. suggest that design models should benchmarked both physics biological data.