Opportunities to improve the effectiveness of complex therapy for endometriosis and chronic pelvic pain in patients of reproductive age

• DOI: 10.17116/repro20232903191
• Publication Date: 2023-07-06T06:16:30Z
• Authors: L.V. Adamyan; M.N. Sharov; K.D. Murvatov; S.I. Kiselev; K.N. Arslanyan; A.S. Chernetsova; Yu.S. Prokofieva

Pain is the most frequent and specific symptom of endometriosis. Objective: To increase the effectiveness of complex therapy of endometriosis patients suffering from chronic pelvic pain. Materials and methods of research. A comparative analysis of the results of examination and treatment of 34 women (18—45 years old) with a histologically verified diagnosis of endometriosis was carried out. The patients were divided into 2 groups: 1 — 12 patients with endometriosis without pain syndrome, 2 — 22 with chronic pelvic pain and endometriosis. Group II is divided into subgroups: 2A — 11 women with chronic pelvic pain, 2B — 11 — with the presence of a neuropathic component of pain syndrome. All patients received dienogest 2 mg day. Group 2A patients additionally received Amitriptyline 12.5 mg at night, and group 2B patients received Clonazepam at a dosage of 2 mg per day at night and non-drug treatment methods. The results obtained. Against the background of ongoing therapy among patients taking Amitriptyline and Clonazepam, the severity of chronic pelvic pain in group 2 decreased by 8 points. The quality of life in group 1 patients increased by 50% by the end of 3 months of treatment, in group 2A patients by 53%, in group 2B patients by 60%. Conclusion. For effective treatment of endometriosis and chronic pelvic pain, an interdisciplinary approach needs to be developed. The drugs Clonazepam and Amitriptyline in combination with non-drug methods of analgesic therapy have demonstrated effectiveness in relieving chronic pain. Study design: comparative prospective.