Kinetic Studies, Antioxidant Activities, Enzyme Inhibition Properties and Molecular Docking of 1,3-Dihydro-1,3-Dioxoisoindole Derivatives

• DOI: 10.17344/acsi.2022.7808
• Publication Date: 2023-03-11T11:36:02Z
• Authors: Hasan Yakan; Seyhan Ozturk; Elvan Uyar Tolgay; Semiha Yenigun; Sarmad Marah; Tugrul Doruk; Tevfik Ozen; Halil Kutuk
• Keywords: Docking (animal); Enzyme Inhibition

The acid catalyzed hydrolysis of the N-(p-substitutedphenyl) phthalimides in three different acids was investigated at 50.0 ± 0.1 °C. Two antioxidant activity tests as DPPH• and ABTS•+ scavenging activities, various enzyme inhibition urease, acetylcholinesterase (AChE), butyrylcholinesterase (BChE) were applied. Compound 3c (2.03 μg/mL ) has higher than other compounds standards according to DPPH test. In AChE assay, 3a 3b (13.13 9.59 μg/mL) standard Galantamine (14.37 μg/mL). BChE urease tests, all (6.84-13.60 10.49-17.73 have (49.40 thiourea (26.19 μg/mL), respectively. molecule interaction for each with active sites AChE, BChE, enzymes examined via molecular docking simulations.