staged induction of hiv 1 glycan dependent broadly neutralizing antibodies

• DOI: 10.17615/a0m6-td59
• Publication Date: 2017-03-15
• Authors: Ashley M. Trama; John R. Mascola; Feng Gao; Feng Gao; John C. Kappes; Kevin O. Saunders; Kevin O. Saunders; Peter T. Hraber; Barton F. Haynes; Barton F. Haynes; M. Anthony Moody; M. Anthony Moody; Brendan W. Pier; Wilton B. Williams; Wilton B. Williams; Lynn Morris; Todd Bradley; Todd Bradley; Hua-Xin Liao; Hua-Xin Liao; Thomas B. Kepler; Shi-Mao Xia; Claudia A. Jette; Kevin Wiehe; Kevin Wiehe; Amit Kumar; George M. Shaw; Ruijun Zhang; Morgan A. Gladden; Bette T. Korber; R. Ryan Meyerhoff; R. Ryan Meyerhoff; Melissa Cooper; Stephen C. Harrison; Daniela Fera; Beatrice H. Hahn; S. Munir Alam; S. Munir Alam; Krisha McKee; Samuel J. Danishe...; Garnett Kelsoe; Garnett Kelsoe; Gift Kamanga; Mark K. Louder; Baptiste Aussedat; Kwan-Ki Hwang; Myron S. Cohen; Kshitij Wagh; Edward F. Kreider; Robert T. Bailer; Anthony Monroe; Mattia Bonsignori; Mattia Bonsignori; William E. Walkowicz; David C. Montefiori; David C. Montefiori
• Keywords: Male; 0301 basic medicine; env Gene Products, Human Immunodeficiency Virus; Crystallography, X-Ray; Antibodies, Neutralizing; 3. Good health; 03 medical and health sciences; Neutralization Tests; Polysaccharides; Mutation; HIV-1; Humans; Phylogeny; Protein Binding

Identification of maturation stages of V3-glycan neutralizing antibodies explains the long duration required for their development.