International consensus guidelines for the diagnosis and management of food protein-induced enterocolitis syndrome: Executive summary-Workgroup Report of the Adverse Reactions to Foods Committee, American Academy of Allergy, Asthma & Immunology

• DOI: 10.17615/rwwd-6217
• Publication Date: 2017-04-01
• Authors: Nowak-Węgrzyn A; Chehade M; Groetch ME; Spergel JM; Wood RA; Allen K; Atkins D; Bahna S; Barad AV; Berin C; Brown Whitehorn T; Burks AW; Caubet JC; Cianferoni A; Conte M; Davis C; Fiocchi A; Grimshaw K; Gupta R; Hofmeister B; Hwang JB; Katz Y; Konstantinou GN; Leonard SA; Lightdale J; McGhee S; Mehr S; Miceli Sopo Stefano; Monti Giovanna; Muraro A; Noel SK; Nomura I; Noone S; Sampson HA; Schultz F; Sicherer SH; Thompson CC; Turner PJ; Venter C; Westcott-Chavez AA; Greenhawt M.
• Keywords: NUTRIENT INTAKE; Allergy; non-IgE-mediated food allergy; Immunology; Dietary Proteins/adverse effects/immunology; WORLD-HEALTH-ORGANIZATION; non–IgE-mediated food allergy; VEGETABLE ACCEPTANCE; 03 medical and health sciences; 0302 clinical medicine; Food protein-induced enterocolitis syndrome; COWS MILK ALLERGY; info:eu-repo/classification/ddc/618; Enterocolitis/diagnosis/immunology/therapy; ATOPY PATCH TEST; Humans; guidelines; SMALL-INTESTINE; ddc:618; Science & Technology; Enterocolitis; CLINICAL-FEATURES; NATURAL-HISTORY; Food Hypersensitivity/complications/diagnosis/therapy; 3. Good health; Food protein–induced enterocolitis syndrome; 1107 Immunology; INITIAL SYMPTOMS; Dietary Proteins; INGLESE; 4 DISTINCT SUBTYPES; Life Sciences & Biomedicine; Food Hypersensitivity

Food protein-induced enterocolitis (FPIES) is a non-IgE cell- mediated food allergy that can be severe and lead to shock. Despite the potential seriousness of reactions, awareness of FPIES is low; high-quality studies providing insight into the pathophysiology, diagnosis, and management are lacking; and clinical outcomes are poorly established. This consensus document is the result of work done by an international workgroup convened through the Adverse Reactions to Foods Committee of the American Academy of Allergy, Asthma & Immunology and the International FPIES Association advocacy group. These are the first international evidence-based guidelines to improve the diagnosis and management of patients with FPIES. Research on prevalence, pathophysiology, diagnostic markers, and future treatments is necessary to improve the care of patients with FPIES. These guidelines will be updated periodically as more evidence becomes available.