Altered plasma glutamate and glutamine levels in patients with drug-resistant and drug-responsive symptomatic focal epilepsy

• DOI: 10.17712/nsj.2021.4.20210041
• Publication Date: 2021-10-18T21:07:27Z
• Authors: Wei Wang; Yanchuan Wu; Xiaoling Li; Lin Li; Ke Sun; Suying Yan
• Keywords: Drug Resistant Epilepsy

<h3>Objectives:</h3> To compare the levels of plasma glutamate and glutamine in drug-resistant or drug-responsive symptomatic focal epilepsy. Dysfunctional neurotransmission plays an essential role epilepsy pathophysiology. <h3>Methods:</h3> This cross-sectional study included 80 42 epileptic patients 132 healthy controls from June 2017 to February 2018. Plasma were assessed via high-performance liquid chromatography. <h3>Results:</h3> Patients with had significantly higher than controls, whereas those disease controls. These results indicate that can discriminate control individuals areas under curve values 0.931 0.72, respectively. <h3>Conclusion:</h3> Elevated are associated may aid diagnosis