The left atrium remodeling is associated with adverse outcomes in unoperated degenerative aortic stenosis

• DOI: 10.17816/clinpract09212-19
• Publication Date: 2018-12-05T16:59:34Z
• Authors: V. I. Safaryan; I. V. Zotova; T. A. Tipteva; O. S. Koroleva; D. A. Zateyshchikov
• Keywords: Ventricular remodeling

Degenerative aortic stenosis (DAS) may be accompanied by remodeling of the left atrium (LA). The aim study was to assess effect morpho-functional parameters LA on prognosis patients with DAS. prospective included 383 (men – 33.9% patients), aged 78.9 ± 0.40 years, DAS (mild 18.3%, moderate 30.8%, severe 50.9%). did not undergo a surgical correction defect. state estimated size/volume and ratio rate transmitral flow early diastolic movement fibrous mitral valve ring (E/e ratio). average follow-up period 603.9 24.57 days. general mortality assessed. information outcomes collected telephone contacts. Multivariate Сox-regression analyses showed that independently associated death risk: an increase in size ≥45 mm (ОR 1.6, CI 1.06-2.37, р=0.026) Е/е >15 1.08-2.39, р=0.021). Another risk factor decrease creatinine clearance <45 ml/min 1.7, 1.10-2.60, р=0.016), area 0.4, 0.26-0.74, р=0.002) ventricular ejection fraction <40% 1.02-2.71, р=0.042). Kaplan-Meier survival analysis E/e ratio>15 LА were statistically significantly increased (р<0.0001, LogRank=14.5 р<0.0001, LogRank=18.2, respectively). areas under ROC curves for 0.62 0.61, respectively. Thus, indices > 15 are poor outcome