Liquid Biopsy as a Method for Minimally Invasive Diagnosis of Thyroid Cancer

• DOI: 10.17816/clinpract321281
• Publication Date: 2023-10-19T17:21:45Z
• Authors: Tagir I. Rakhmatu...; Mark Jain; Larisa M. Samokho...; Vladimir A. Zhivotov
• Keywords: Liquid biopsy; Medullary Thyroid Cancer

Thyroid cancer is the 9th most common in world. The five-year survival rate for this disease over 98%. However, some patients there are cases of rapidly progressive treatment-resistant that cannot be differed from poor-invasive by routine methods. Liquid biopsy could one methods to solve problem. This procedure consists analysis tumor derivatives (in particular, circulating DNA) body fluids. hotspot mutations and patterns epigenetic regulation, which usual neoplasms with a certain genotype, used identify component total mass DNA. increase DNA plasma observed several months ahead characteristic signs at MR images patients, also surpasses conventional biomarkers such as calcitonin medullary thyroid carcinoma. In addition, possibility minimally invasive determination genotype analyzing important select optimal chemotherapy. review discusses current advances cancers papillary, follicular, medullary, anaplastic carcinomas.