The role of polymorphisms in the genes of the hemostasis system and the folate-methionine cycle in the development of recurrent pregnancy loss

• DOI: 10.17816/jowd112514
• Publication Date: 2023-09-28T18:14:27Z
• Authors: Larisa D. Belotse...; Lyudmila V. Koval...; Inna I. Mordovina; Maksim Yu. Donnikov; Aisel E. Babaeva
• Keywords: Early Pregnancy Loss; Recurrent miscarriage

BACKGROUND:Recurrent pregnancy loss is a serious clinical problem that complicates about 2% of pregnancies. There evidence thrombophilia and disorders folate-methionine metabolism may cause recurrent loss.
 AIM:The aim this study was to evaluate the contribution polymorphic variants genes hemostasis system cycle in women with MATERIALS AND METHODS:Clinical examination 406 pregnant divided into two groups carried out. The main group consisted 206 or more losses known up 12 weeks pregnancy; control included 200 apparently healthy history live births, no spontaneous induced abortions, infertility, endometriosis. All patients underwent molecular genetic single nucleotide polymorphisms performed by real-time polymerase chain reaction.
 RESULTS:We studied eight involved four cycle. An association presence alternative such as 1565C (rs5918) theITGB3integrin beta-3 gene A66G (rs1801394) theMTRRmethionine synthase reductase development found. frequency their occurrence 29.1 77.7% vs. 12.0 49.0% group, respectively (p 0.01). combined carriage theITGB3gene theMTRRgene diagnosed often than amounted 47 (22.8%) (6.0%) cases ( = 5.047;p 0.01; odds ratio 3.631; 95% confidence interval 2.3749.034). We have thus developed three-locus model synergetic action allelic above early [10976 GA (rs6046) theF7, 455 (rs1800790) theFGB, 1565 TC theITGB3] reproducibility 8/10, sensitivity 65.6%, specificity 68.8% 15.7415,p 0.0001; 3.341, 1.8246.118).
 CONCLUSIONS:This allows for confirming hypothesis status theITGB3andMTRRgenes three polymorphisms: rs6046 rs1800790 rs5918 theITGB3may be used predictors development.