Peculiarities of placental microRNA expression in pregnancies complicated by gestational diabetes mellitus and preeclampsia

• DOI: 10.17816/jowd663110-115
• Publication Date: 2017-07-19T05:14:26Z
• Authors: Vladimir S. Pakin; Elena S. Vashukova; Roman V. Kapustin; Olga N. Arzhanova; Andrey S. Glotov; Vladislav S. Baranov
• Keywords: Pathogenesis

The aim of study was to determine feasible changes placental miRNAs expression profiles revealed by next generation sequencing (NGS) in pregnancies with GDM complicated or not PE. Out 27 miRNAs, studied significantly different (FDR < 0.05) only for his-miR-45a. Comparative analysis reliable differences hsa-miR-4532 (p 0.0001, FDR = 0.0008), hsa-miR-34c-5p 0.0083), and hsa-miR-193b-5p 0.0139) pregnancy PE, without GDM. present results suggest that PE are associated specific alterations the miRNA profiles. Further studies needed verify role these microRNA molecular mechanisms underlying pathogenesis.