Consensus “Cystic Fibrosis: definition, diagnostic criteria, treatment” Section “Microbiology and Epidemiology of chronic respiratory infections in cystic fibrosis”

• DOI: 10.17816/ped7180-96
• Publication Date: 2016-05-25T17:05:23Z
• Authors: Igor A Shaginyan; Marina Yu Chernukha; Nikolay I Kapranov; Elena I Kondratyeva; Nataliya Yu Kashi...; Elena L Amelina; Irina K Asherova; Igor K Volkov; T E Gembitskaya; Evgeniy K Ginter; Nataliya A Ilyenkova; Irina P Karimova; Stanislav A Kraso...; Nina B Merzlova; Ludmila P Nazarenko; Leila S Namazova-...; Alla F Neretina; Victoria S Nikonova; Aleksandr V Orlov; Sergei S Postnikov; Tatiyana A Protasova; Sergei Yu Semykin; Diana F Sergienko; Olga I Simonova; Irina D Uspenskaya; Lidiya A Shabalova; Victoria D Sherman
• Keywords: Achromobacter xylosoxidans; Stenotrophomonas maltophilia; Burkholderia cenocepacia; Chronic infection

The main causative agents of lung infection in patients with cystic fibrosis (CF) are P. aeruginosa, S. aureus and H. influenzae. In the last decade, gram-negative nonfermentative microorganisms (NFMO) - Вurkholderia cepacia complex (Bcc), Stenotrophomonas maltophilia, Achromobacter xylosoxidans non-tuberculous mycobacteria, fungi genus Aspergillus have acquired clinical significance. It is found that chronic 2/3 cases caused by association microorganisms. Among hospitalized patients, contrast to outpatients, these associations represented two, three or more species aeruginosa + (18,2 %) Bcc (9,1 most common. Other representatives A. xylosoxidans, maltophilia baumanii often identified focuses infections formed increasing age. dominant pathogens aureus. methicillinresistant staphylococci strains a mucoid phenotype particular importance for patients. isolates from Russia belong genomovar III A-B. cenocepacia. colonize lower airways CF able long-term persistence transmission patient patient. resistance many antibiotics feature strains. atypical (small colony variants) under action antibiotic. Infections other NFMO difficult identify we need use wide range bacteriological, biochemical, molecular biological techniques mass spectrometry.