Sıçanlarda karaciğer iskemi/reperfüzyon hasarında papaverinin etkisi

• DOI: 10.17941/agd.46853
• Publication Date: 2012-04-01
• Authors: Gür, Emine Özlem ...; HACİYANLI, MEHMET; BAĞRIYANIK, HÜSNÜ...; TAVUSBAY, CENGİZ; ATAHAN, MURAT KEMAL; YILMAZ, OSMAN; Yolcuoğlu, Burhan; Genç, Hüdai; GÜREŞ, NAZIM

Background and Aims: The present study aimed to investigate the in volvement of the phosphodiesterase inhibitor and vasodilator papaverine in hepatic ischemia-reperfusion injury. Materials and Methods: The study was conducted in the Experimental Animals Laboratory of Dokuz Eylul University. Totally, 21 female Wistar albino rats were divided into three groups as: (1) Sham Group: the abdomen was surgically opened and closed without any surgical procedure. (2) Control Group: the hepatic portal triad was clipped with microvascular clips and 20 mg/kg normal saline was administered 30 minutes after the ischemia. (3) Experimental (Papaverine) Group: the portal triad was clipped as described above and 20 mg/kg papaverine was administered 30 minutes after the ischemia. Sixty-minutes of ischemia followed by 120 minutes of reperfusion were induced in Groups 2 and 3. Histopathological evaluation of the damage was performed according to Suzukias scoring system. The sections were analyzed for hydropic swelling, granular degeneration, microvesicular vacuolization, macrovesicular vacuolization, and focal necrosis cord disorder in the parenchyma, for inflammation and fibrosis in the portal area, and for hyperemia in the sinusoids. Results: According to the statistical evaluation of our study, it was shown that ischemia-reperfusion injury was significantly reduced in the study group compared with the control in all parameters except focal necrosis and hydropic swelling. Conclusions: We concluded that papaverine may reduce damage in a hepatic ischemia-reperfusion model.