Prognostic Value of Melatonin Level, Structural and Functional Changes of the Myocardium in the Development of Complications in Patients With Heart Failure who Underwent Coronary Artery Bypass Grafting: the Possibilities of Pharmacological Cardioprotection

• DOI: 10.18087/cardio.2017.10.10040
• Publication Date: 2018-02-12T12:10:21Z
• Authors: Y. V. Liskova; ; A. A. Stadnikov; ; S. P. Salikova; ; N. B. Tverdokhlib; ; V. O. Rozhkov; ; G. M. Avchenko; ; A. Y. Erkhov; ; A. B. Popov; ; S. A. Selivanov
• Keywords: Heart Failure; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Myocardium; Humans; Coronary Artery Bypass; Prognosis; Melatonin; 3. Good health

Objective. To assess the significance of melatonin, NT-proBNP and morphological markers myocardial remodeling for predicting risk complications after coronary artery bypass grafting (CABG) in patients with ischemic heart disease chronic failure (CHF). Materials methods. We included this study 83 who underwent CABG period from September 2013 to October 2014. All before standard laboratory instrumental examination. Concentrations melatonin were measured 2 days surgery. The evaluation (expression MT2 receptors [MTR2], caspase-3, bcl-2) was carried out tissue samples taken at biopsies right atrial appendage during CABG. Results. Analysis groups favorable unfavorable hospital outcomes revealed no significant differences serum levels NT-proBNP. There a decrease level subgroup outcome combination high comorbid load degree apoptosis cardiomyocytes background moderate MTR2 expression. Comparative assessment pharmacotherapy prior effect on perindopril amlodipine. Conclusion. Preoperative sulfate, markers, can serve as prognostic factors complicated course postoperative CHF. amlodipine preserved ejection fraction exerted cardioprotective myocardium, contributing apoptotic dominant.