Gut microbiota and systemic inflammation in patients with chronic heart failure

• DOI: 10.18087/cardio.2020.5.n859
• Publication Date: 2020-06-09T12:38:27Z
• Authors: A. A. Vlasov; S. P. Salikova; V. B. Grinevich; O. V. Bystrova; G. A. Osipov; M. E. Meshkova
• Keywords: Heart Failure; Inflammation; 03 medical and health sciences; 0302 clinical medicine; Clostridioides difficile; Chronic Disease; Natriuretic Peptide, Brain; Humans; Biomarkers; Peptide Fragments; Gastrointestinal Microbiome; 3. Good health

Aim To study the interrelationship between intensity of chronic systemic inflammation (CSI) with severity condition and intestinal microbiocenosis parameters in patients heart failure (CHF). Material methods 47 hospitalized symptomatic CHF were evaluated. The following determined: clinical condition; N-terminal pro-B-type natriuretic peptide (NT-proBNP). C-reactive protein (CRP); serum interleukins (IL) 6 10; composition by mass-spectrometry microbial markers whole blood. Microbiocenosis indexes compared main group 38 outpatient arterial hypertension ischemic disease without CHF. Results Direct, medium-power correlations found CRP IL-6 concentrations (NT-proBNP, ХСН stage, edema severity) Most had lower numbers bifido-, lacto-, propionic-, eubacteria, Clostridium (С.) ramosum higher aspergillus. Among patients, highest endotoxemia, gram (-) bacteria, cocci, actinomycetes, microfungi observed NT-proBNP from 400 to 2000 pg/ml. Direct for amounts C. hystolyticum, Pseudonocardia spp., Aspergillus spp. IL-10 unidirectional inverse correlation these cytokines Propionibacterium acnes jensenii, Streptomyces Nocardia asteroides. In addition, concentration was negatively correlated contents Staphylococcus aureus, difficile, ramosum, Eggerthella lenta, Corynebacterium positively propionicum, Moraxella Flavobacterium Concentration directly number Eubacterium inversely Ruminicoccus farmamarensis. amount farmamarensis concentrations. Conclusion results evidence significance microbial-tissue complex pathogenesis CSI allow suggesting this as a promising target therapy.