Relationship of Apolipoprotein B to Aortic Aneurysm: Frailty Index as a Partial Mediator – a Mendelian Randomization Study

• DOI: 10.18087/cardio.2025.2.n2796
• Publication Date: 2025-03-07T14:32:11Z
• Authors: Tongxue Zhang; Yajing Li; Xiaoyu Liu; Jinfeng Wang; Danlei Chen; Hanyu Lei; Yupeng Zhang; Huanhuan Lin; Yizhen Jia; Lin Xu; Keyang Duan
• Keywords: Mendelian Randomization; Univariate analysis; Thoracic aortic aneurysm

Aim Aortic aneurysm is characterized by localized expansion and damage to the vessel wall. While apolipoprotein B (ApoB) has been linked atherosclerosis, its causal relationship with aortic remains unclear. This study used a Mendelian randomization (MR) approach explore relationships between ApoB, aneurysm, potential mediators. Material methods Single nucleotide polymorphism (SNP) data related A1 (ApoA1), triglycerides, frailty index, were obtained from large-scale genome-wide association studies. MR analysis was conducted evaluate relationships, using inverse variance weighting (IVW) as primary statistical method. Additionally, we assessed whether index mediates ApoB aneurysm. Results Univariate revealed that significantly associated (IVW odds ratio (OR) = 1.443, 95 % confidence interval (CI) 1.273–1.637, p < 0.001). Multivariable (MVMR) analysis, adjusted for ApoA1 confirmed these results. In mediation found partially mediate effect of on (mediation contribution: 20.1 %–23.1 %). The ORs respect 1.325 (95 CI 1.168–1.505) 4.188 1.859–9.435), respectively. Conclusion acting partial mediator in this pathway.