The role of lipids in the classification of astrocytoma and glioblastoma using MS tumor profiling

• DOI: 10.18097/pbmc20206604317
• Publication Date: 2020-09-04T14:01:44Z
• Authors: V.A. Eliferov; E.S. Zhvansky; A.A. Sorokin; V.A. Shurkhay; D.S. Bormotov; S.I. Pekov; P.V. Nikitin; M.V. Ryzhova; E.E. Kulikov; A.A. Potapov; E.N. Nikolaev; I.A. Popov
• Keywords: Profiling (computer programming); Brain tumor

Express MS identification of biological tissues has become a much more accessible research method due to the application direct specimen ionization at atmospheric pressure. In contrast traditional methods analysis employing GC-MS for determining molecular composition analyzed objects it eliminates influence mutual ion suppression. Despite significant progress in field tissues, question mass spectrometric profile attribution certain type tissue still remains open. The use modern machine learning and protocols (e.g., "random forests") enables us trace possible relationships between components sample result brain tumor classification (astrocytoma or glioblastoma). It been shown that most pronounced differences profiles these tumors are their lipid composition. Detection statistically astrocytoma glioblastoma may be used perform an express test during surgery inform neurosurgeon what malignant he is working with. ability accurately determine boundaries neoplastic growth significantly improves quality both surgical intervention postoperative rehabilitation, as well duration life patients.Ékspress-identifikatsiia biologicheskikh tkaneĭ stala sushchestvenno bolee dostupnym metodom issledovaniia blagodaria primeneniiu metodov mass-spektrometrii s priamoĭ atmosfernoĭ ionizatsieĭ. V otlichie ot traditsionnykh analiza, ispol'zuiushchikh khromato-mass-spektrometricheskie metody opredeleniia molekuliarnykh komponent issleduemykh ob"ektov, ona iskliuchaet vozmozhnost' ucheta éffektov podavleniia razlichnymi ionami drug druga po rezul'tatam izmereniĭ. Nesmotria na sushchestvennyĭ v oblasti tkaneĭ, vopros atributsii mass-spektrometricheskogo profilia opredelennomu vidu tkani ostaetsia otkrytym. Primenenie sovremennykh mashinnogo obucheniia (sluchaĭnykh lesov) pozvoliaet prosledit' vzaimosviaz' mezhdu komponentami i rezul'tatom identifikatsii opukholi mozga (astrotsitomy ili glioblastomy). dannoĭ rabote pokazano, chto osnovnye otlichiia mass-spektrometricheskikh profiliakh étikh opukholeĭ obuslovleny ikh lipidnym sostavom. Poluchenie statisticheski dostovernykh razlichiĭ lipidnykh profileĭ astrotsitomy glioblastomy bystro provodit' analiz vo vremia khirurgicheskoĭ operatsii soobshchat' neĭrokhirurgu, kakoĭ tkan'iu on rabotaet. Vozmozhnost' tochnogo granits novoobrazovaniia uluchshaet kachestvo operativnogo vmeshatel'stva, postoperatsionnoĭ reabilitatsii, ravno kak prodolzhitel'nost' zhizni patsientov.